Gluten Intolerance

At long last the Cyrex gluten intolerance tests are available in the UK. Cyrex is a US based clinical immunology laboratory specialising in autoimmunity.

Standard blood tests for Coeliac Disease vary in accuracy depending on the degree of villous atrophy present. Gluten has to have significantly destroyed the gut wall for current blood testing to show a positive result. Also, the current blood test only tests for one peptide of gluten. Recent research has identified over 60 and any of these antigens can challenge the immune system. Standard blood tests can result in false negatives for both coeliac disease and gluten intolerance. Many know that they react adversely to gluten but until now an accurate test has not been available. Auto-immunity particularly is ten times more common in gluten sensitive individuals.

The new generation of Cyrex tests can identify gluten sensitivity to a wider range of gluten peptides. Current research tells us that the peptides of gluten may detrimentally affect any tissue in the body and are not restricted to the intestines. Affected tissues can also be skin, muscles, brain or nervous system. The tests are particular appropriate for any sufferers of autoimmunity, such as MS, Crohn’s disease, ulcerative colitis, rheumatoid arthritis and psoriasis. Current research has linked multiple symptom complaints such as chronic fatigue syndrome and fibromyalgia to gluten intolerance. Pathology to gluten exposure can occur in multiple systems without any evidence of intestinal damage.

In addition gluten contains specific opioid peptides that in sensitive individuals can create a systemic opiate effect, manifesting as the frequently described “brain fog”, mood swings, anxiety, depression and behavioral problems. Testing is now possible for the specific opioid peptides, Gluteomorphin and Prodynorphin.